| City | Region |
|---|
| ›Sabz Chashmah | Badakhshan› |
| ›Sabz Darah | Badakhshan› |
| ›Sabz Sang | Kabul (Kabol)› |
| ›Sabzi Bahar | Badakhshan› |
| ›Safed Ab | Badakhshan› |
| ›Safed Chut | Badakhshan› |
| ›Şah Vali Kot | Kandahar› |
| ›Sahor | Daykundi› |
| ›Saidan | Helmand› |
| ›Saidullah | Parwan› |
| ›Saifuddin Khel | Ghazni› |
| ›Sakaflar | Balkh› |
| ›Sakhiabad | Balkh› |
| ›Salang | Parwān› |
| ›Salang | Baghlan› |
| ›Salet | Badakhshan› |
| ›Salmah | Herat› |
| ›Salmazan | Jowzjan› |
| ›Saltiq-e Khord | Jowzjan› |
| ›Saltiq-e Now | Jowzjan› |
| ›Samadkhankalay | Helmand› |
| ›Sameda | Parwān› |
| ›Samur | Farah› |
| ›San-e Sangi | Ghor› |
| ›Sandar Khel | Parwan› |
| ›Sang Ab | Badakhshan› |
| ›Sang-e Shandeh | Balkh› |
| ›Sangamum | Daykundi› |
| ›Sangchal | Helmand› |
| ›Sangchil | Bamyan› |
| ›Sange Masa | Ghazni› |
| ›Sangin | Helmand› |
| ›Sanglich (Sanglac) | Badakhshan› |
| ›Sangolak | Farah› |
| ›Sar AsyAb | Kabul (Kabol)› |
| ›Sar Chashmah | Balkh› |
| ›Sar Darah | Badakhshan› |
| ›Sar Deh | Herat› |
| ›Sar Nagaw | Daykundi› |
| ›Sar Rostaq | Takhar› |
| ›Sar-e Band | Samangan› |
| ›Sar-e Deh | Badakhshan› |
| ›Sar-e Kalan | Ghazni› |
| ›Sar-e Piadah Rah | Balkh› |
| ›Sar-e Pul (Sar-i-Pul) | Sar-e Pul› |
| ›Sar-e Raqol (Sar-e Raqowl) | Wardak› |
| ›Sar-e Wuzan | Balkh› |
| ›Sar-e-Kowtal | Bamyan› |
| ›Sarab | Balkh› |
| ›Sarawbi | Kabul (Kabol)› |
| ›Sardar | Helmand› |
| ›Sardar Khel | Logar› |
| ›Sardarah | Balkh› |
| ›Saresang | Badakhshan› |
| ›Sarinj | Daykundi› |
| ›Sarjangal | Ghor› |
| ›Sarnay | Daykundi› |
| ›Sarqowl | Ghazni› |
| ›Sartasan | Ghazni› |
| ›Sast | Badakhshan› |
| ›SayAd | Parwān› |
| ›Saybak | Parwan› |
| ›Saykhabad | Ghazni› |
| ›Sayyad | Baghlan› |
| ›Sayyidabad | Jowzjan› |
| ›Sayyidan | Daykundi› |
| ›Sedekhel | Paktia› |
| ›Seh Ab | Takhar› |
| ›Seh Dewal | Ghazni› |
| ›Seh Mahah | Balkh› |
| ›Senwari | Parwan› |
| ›Sera Tala | Takhar› |
| ›Serkani (Sarkani) | Kunar› |
| ›Shaban | Helmand› |
| ›Shah Ab | Balkh› |
| ›Shah Karez | Kandahar› |
| ›Shah Mari | Badakhshan› |
| ›Shah-e Pari | Badakhshan› |
| ›Shahi Kelay | Zabol› |
| ›Shahr Biland | Panjshir› |
| ›Shahr-e Buzurg | Badakhshan› |
| ›Shahr-e Kuhnah | Helmand› |
| ›Shahrak | Ghor› |
| ›Shahran | Badakhshan› |
| ›Shahzadeh | Ghazni› |
| ›Shakarak Bazar | Jowzjan› |
| ›Shakardara | Kabul (Kabol)› |
| ›Shakardarah | Daykundi› |
| ›Shakhmuradkheyl | Parwan› |
| ›Shalkachah | Panjshir› |
| ›Shālzōr | Panjshir› |
| ›Shamalak | Balkh› |
| ›Shamali Gudali | Ghazni› |
| ›Shaniz | Panjshir› |
| ›Sharan | Paktika› |
| ›Sharistan | Daykundi› |
| ›Shash Paikal | Balkh› |
| ›Shaykari (Shekari) | Bamyan› |
| ›Shaykh Ali | Parwan› |
| ›Shaykh Zai | Helmand› |
| ›Sheray | Helmand› |
| ›Sheray | Ghazni› |
| ›Sherbatay | Farah› |
| ›Shergar | Nangarhar› |
| ›Sherkhey | Ghazni› |
| ›Sherzad | Nangarhar› |
| ›Sheykhabad | Wardak› |
| ›Sheywah | Nangarhar› |
| ›Shib Koh | Farah› |
| ›Shibirghān (Sheberghān) | Jowzjan› |
| ›Shindand | Herat› |
| ›Shini | Badakhshan› |
| ›Shinwar | Nangarhar› |
| ›Shipun | Badakhshan› |
| ›Shirin Tagab | Faryab› |
| ›Shiwar Khel | Kabul (Kabol)› |
| ›Shoghleh | Ghazni› |
| ›Sholgarah | Balkh› |
| ›Shor Tepe | Balkh› |
| ›Shora Gaz | Helmand› |
| ›Shorabi | Balkh› |
| ›Shorakian | Helmand› |
| ›Shorawak | Kandahar› |
| ›Shosh-E Oyla | Daykundi› |
| ›Showrak (Shorak) | Balkh› |
| ›Shur Tughay | Takhar› |
| ›Sidyah | Badakhshan› |
| ›Sigman | Panjshir› |
| ›Sikan | Paktia› |
| ›Sindew | Badakhshan› |
| ›Sindzaray (Senjaray) | Kandahar› |
| ›Singan | Takhar› |
| ›Sipah | Badakhshan› |
| ›Siyah Bum-e Shughlah | Ghazni› |
| ›Siyah Now | Balkh› |
| ›Siyah Tal | Balkh› |
| ›Siyahgird | Parwan› |
| ›Smad Khan Kelay | Helmand› |
| ›Sōmagā | Balkh› |
| ›Sorkh Doz | Helmand› |
| ›Sorsaynak | Wardak› |
| ›Spin Baldak | Kandahar› |
| ›Sufiha | Ghor› |
| ›Sultan Baba Ali Sher | Balkh› |
| ›Sululuk | Takhar› |
| ›Sum Darah | Badakhshan› |
| ›Sumlī | Faryab› |
| ›Sur Kelay | Nangarhar› |
| ›Sur Pol | Wardak› |
| ›Surkh Ab (Sorkh Ab) | Farah› |
| ›Surkh Kanak | Daykundi› |
| ›Surkh Rod | Nangarhar› |
| ›Surkhe Parsa | Parwān› |
| ›Surkhya | Balkh› |
| ›Surki | Ghazni› |
| ›Surobi | Kabul (Kabol)› |
| ›Suwarz | Herat› |
