| City | Region |
|---|
| ›Sambuli | Khatlon› |
| ›Samgar | Sughd› |
| ›Samgar | Sughd› |
| ›Sangdarai Ubara | Khatlon› |
| ›Sangistan | Sughd› |
| ›Sarband | Khatlon› |
| ›Sarchinor | Nohiyahoi Tobei Jumhurí› |
| ›Sarchinori Bolo | Nohiyahoi Tobei Jumhurí› |
| ›Sargay (Sarigon) | Region of Republican Subordination› |
| ›Sarykamysh | Khatlon› |
| ›Savadkhi-Poypn | Sughd› |
| ›Shahrinav | Sughd› |
| ›Shahriston | Sughd› |
| ›Shakhrinav | Khatlon› |
| ›Shamtuch | Sughd› |
| ›Shavadki-Bolo | Sughd› |
| ›Shirinbuloq | Khatlon› |
| ›Sholipoya | Nohiyahoi Tobei Jumhurí› |
| ›Shopur | Region of Republican Subordination› |
| ›Shorazm | Nohiyahoi Tobei Jumhurí› |
| ›Shrcha | Khatlon› |
| ›Shurab | Sughd› |
| ›Sirdaryo | Sughd› |
| ›Sovet | Khatlon› |
| ›Sultonobod | Sughd› |
| ›Surkh | Region of Republican Subordination› |
| ›Surkhakchasma | Region of Republican Subordination› |
